I’ve been thinking lately about whether alcoholism is really
inherited or not. I found this article very interesting. Wouldn’t it
be cool if scientists could find the exact gene that causes alcoholism
and then find a cure for this awful disease?
(Ivanhoe Newswire) — A mutation found in a mouse gene may provide new insights into the genetic roots of alcoholism in humans.
The mutation, which researchers at the Ernest Gallo Clinic and Research Center and
the University of California,
San Francisco, have named Lightweight, is in the mouse version of a
gene called unc-79. Previous studies in worms and flies have shown that
unc-79 is associated with altered sensitivity to a variety of
anesthetics,
including alcohol. The mutant mice are more sensitive to alcohol than
their normal, wild-type littermates, and voluntarily consume more
alcohol than normal mice when offered the choice between alcohol and
water. Lead author Dr. David Speca was quoted as saying that the name
Lightweight refers to the observation that when unc-79 mutant mice were
injected with high doses of alcohol “they were knocked out for far
longer than normal mice.”
The function of unc-79 is not well understood, said Speca, but he
noted that experiments by other researchers suggest it may interact with
a particular neuron channel named NALCN to influence neuronal responses
to alcohol. A neuron channel is a complex of proteins essential to
nerve cell function.
Although this study did not demonstrate an interaction with this
channel in Lightweight mice, Speca said that follow-up experiments in
the roundworm Caenorhabditis elegans showed that the NALCN channel
influences responses to alcohol, “suggesting that this response may be
conserved from worms to mice to humans.”
Studies of human twins have suggested that there is a genetic
component to alcoholism, but, according to Speca, it is likely that
there are multiple genes that contribute to the disease, each with its
own effect, making it difficult to identify any single cause. The
question now, he said, is whether unc-79 and the NALCN neuron channel
turn out to be associated with altered responses to alcohol in humans.
“Nobody has ever studied these genes in humans before,” noted Speca.
“There’s a chance that it’s part of a new and relatively unexplored
biochemical
pathway that may tell us something about human susceptibility to alcoholism.”
SOURCE: PLoS Genetics, August 19, 2010.